PHKB

Across TCGA pan-cancer cohorts, PHKB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PHKB data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PHKB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PHKB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where PHKB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.966	0.779	.004	30	view →
LUAD	OS	Quartile	All	0.624	0.923	.009	10	view →
UCEC	DFS	Median	All	0.916	0.787	.036	2	view →
LSCC	DFS	Median	All	0.892	1.000	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PHKB–CCRCC (DFS)

Open the CCRCC breakdown →