PHKB

Across TCGA cell cohorts, PHKB mutation is significantly associated with the RNA expression of many other genes, with 1,001 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHKB-associated genes across cancer lineages are TEX43, CASP8AP2, and IER3IP1. Each is linked with PHKB in more than 1 cancer types. Because this analysis shows association rather than direction, both PHKB-to-partner and partner-to-PHKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX43 grouped by PHKB-low versus PHKB-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKB→partner) and Y-score (partner→PHKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TEX43 →	+0.245	+4.523	<.001	.003	3	2
LARGE_INTESTINE	CASP8AP2 →	+0.535	+3.234	.003	.004	3	2
LARGE_INTESTINE	IER3IP1 →	+0.650	+2.628	.002	.002	3	2
LARGE_INTESTINE	PPA2 →	+0.727	+2.628	<.001	.002	3	2
PANCREAS	OR2T35 →	+0.015	+4.614	<.001	.004	3	1
PANCREAS	UBE2U →	+0.291	+4.011	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,001 associations by consensus.

TEX43 by PHKB expression — LUNG_SCLC

Explore this box plot interactively →