PHKA2

Across TCGA patient cohorts, PHKA2 mutation is significantly associated with the RNA expression of many other genes, with 7,099 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHKA2-associated genes across cancer lineages are SRP54, FECH, and OXA1L. Each is linked with PHKA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PHKA2-to-partner and partner-to-PHKA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRP54 grouped by PHKA2-low versus PHKA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKA2→partner) and Y-score (partner→PHKA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SRP54 →	+0.413	+1.396	<.001	<.001	3	5
COAD	FECH →	+0.699	+3.392	<.001	.004	3	4
UCEC	OXA1L →	+0.213	+1.315	<.001	.003	3	4
UCEC	DCK →	+0.569	+1.477	<.001	<.001	3	4
UCEC	SUSD3 →	-0.542	-1.643	.002	.002	3	4
UCEC	CDC42SE2 →	+0.370	+1.684	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,099 associations by consensus.

SRP54 by PHKA2 expression — UCEC

Explore this box plot interactively →