PHKA2

Across TCGA cell cohorts, PHKA2 mutation is significantly associated with the RNA expression of many other genes, with 229 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHKA2-associated genes across cancer lineages are CYLC2, DGKK, and SEC14L4. Each is linked with PHKA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHKA2-to-partner and partner-to-PHKA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYLC2 grouped by PHKA2-low versus PHKA2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKA2→partner) and Y-score (partner→PHKA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CYLC2 →	+0.012	+4.357	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	DGKK →	+0.005	+4.357	<.001	.006	3	2
BLOOD_Myeloma	SEC14L4 →	+0.016	+3.906	<.001	.009	3	1
BLOOD_Myeloma	C1orf94 →	+0.007	+4.754	<.001	<.001	3	1
BLOOD_Myeloma	DIPK1C →	+0.015	+3.906	.004	.009	3	1
BLOOD_Myeloma	TCEAL6 →	+0.029	+4.285	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 229 associations by consensus.

CYLC2 by PHKA2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →