PHKA1

Across TCGA patient cohorts, PHKA1 mutation is significantly associated with the RNA expression of many other genes, with 3,947 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHKA1-associated genes across cancer lineages are RNU6-484P, MEX3D, and TBPL1. Each is linked with PHKA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHKA1-to-partner and partner-to-PHKA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-484P grouped by PHKA1-low versus PHKA1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKA1→partner) and Y-score (partner→PHKA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-484P →	+0.500	+2.913	.008	.004	3	4
UCEC	MEX3D →	+0.590	+1.649	<.001	<.001	3	4
BLCA	TBPL1 →	+0.543	+3.202	<.001	.009	3	3
UCEC	SART1 →	+0.222	+2.021	.005	<.001	3	3
UCEC	UFD1 →	+0.392	+1.860	<.001	<.001	3	3
UCEC	DAZAP1 →	+0.315	+2.453	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,947 associations by consensus.

RNU6-484P by PHKA1 expression — LUAD

Explore this box plot interactively →