PHKA1

Across TCGA cell cohorts, PHKA1 mutation is significantly associated with the RNA expression of many other genes, with 118 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHKA1-associated genes across cancer lineages are PNMA6F, CYP4A11, and GAGE2A. Each is linked with PHKA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHKA1-to-partner and partner-to-PHKA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNMA6F grouped by PHKA1-low versus PHKA1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKA1→partner) and Y-score (partner→PHKA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PNMA6F →	+0.006	+5.000	<.001	.005	3	2
BLOOD_Leukemia	CYP4A11 →	+0.050	+4.705	<.001	.003	3	2
KIDNEY	GAGE2A →	+0.883	+5.000	<.001	.005	3	1
KIDNEY	LORICRIN →	+0.013	+5.000	<.001	.005	3	1
KIDNEY	PRAMEF20 →	+0.013	+5.000	<.001	.005	3	1
KIDNEY	KRTAP4-7 →	+0.033	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 118 associations by consensus.

PNMA6F by PHKA1 expression — KIDNEY

Explore this box plot interactively →