PHKA1

Across TCGA cell cohorts, PHKA1 mutation is significantly associated with the mutation status of many other genes, with 3,399 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHKA1-associated genes across cancer lineages are IFIH1, REV3L, and MXRA5. Each is linked with PHKA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PHKA1-to-partner and partner-to-PHKA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFIH1 grouped by PHKA1-low versus PHKA1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKA1→partner) and Y-score (partner→PHKA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IFIH1 →	+3.731	+3.554	.003	.003	1	5
BLOOD_Lymphoma	REV3L →	+2.731	+3.289	.003	.003	1	5
CNS	MXRA5 →	+3.541	+4.139	.003	.003	1	4
CNS	TGM5 →	+5.277	+4.459	.005	.005	1	4
SKIN	GDA →	+3.772	+3.772	.003	.003	1	4
BLOOD_Leukemia	VCAN →	+2.202	+3.442	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,399 associations by consensus.

IFIH1 by PHKA1 expression — BLOOD_Lymphoma

Explore this box plot interactively →