PHIP

Across TCGA pan-cancer cohorts, PHIP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PHIP data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PHIP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PHIP expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where PHIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.893	0.985	.011	14	view →
LSCC	DFS	Quartile	All	0.819	0.469	.003	12	view →
LUAD	OS	Median	All	1.000	0.758	.003	7	view →
PDAC	OS	Quartile	II,III,IV	0.330	0.569	.010	7	view →
UCEC	OS	Tertile	All	0.868	1.000	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PHIP–CCRCC (OS)

Open the CCRCC breakdown →