PHGR1

Across TCGA cell cohorts, PHGR1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHGR1-associated genes across cancer lineages are AMELY, WFDC6, and ZPBP2. Each is linked with PHGR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHGR1-to-partner and partner-to-PHGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMELY grouped by PHGR1-low versus PHGR1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHGR1→partner) and Y-score (partner→PHGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AMELY →	+0.028	+5.000	<.001	<.001	3	1
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	1
CNS	ZPBP2 →	+0.089	+5.754	<.001	.002	3	1
CNS	PRAMEF15 →	+0.345	+4.981	<.001	.008	3	1
CNS	LEUTX →	+0.223	+5.321	<.001	.005	3	1
CNS	PRAMEF5 →	+0.459	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

AMELY by PHGR1 expression — SKIN

Explore this box plot interactively →