PHGDH

Across TCGA pan-cancer cohorts, PHGDH mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PHGDH data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PHGDH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PHGDH expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

COAD, LUAD, and PDAC are the cancer types where PHGDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	1.000	0.844	.044	12	view →
LUAD	DFS	Median	III,IV	0.504	0.977	.005	11	view →
PDAC	DFS	Median	III,IV	0.463	0.813	.033	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PHGDH–COAD (DFS)

Open the COAD breakdown →