PHGDH

Across TCGA patient cohorts, PHGDH RNA expression is significantly associated with the protein abundance of many other proteins, with 18,931 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PHGDH-associated proteins across cancer lineages are PHGDH_S349, ASNS, and ADNP. Each is linked with PHGDH in more than 7 cancer types. Because this analysis shows association rather than direction, both PHGDH-to-partner and partner-to-PHGDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHGDH versus PHGDH_S349 in BRCA, with a Pearson correlation of 0.65.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PHGDH→partner) and Y-score (partner→PHGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PHGDH_S349 →	+0.994	+1.860	<.001	<.001	3	8
LSCC	ASNS →	+0.745	+1.022	<.001	<.001	3	7
GBM	ADNP →	+0.307	+0.718	.001	<.001	3	7
LSCC	RIF1 →	+0.555	+1.258	<.001	<.001	3	7
BRCA	PSAT1 →	+0.952	+1.164	<.001	<.001	3	7
LSCC	VRK1 →	+0.504	+0.835	.005	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,931 associations by consensus.

PHGDH vs PHGDH_S349 — BRCA

Explore this scatter interactively →