PHGDH

Across TCGA patient cohorts, PHGDH protein abundance is significantly associated with the RNA expression of many other genes, with 13,518 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PHGDH-associated genes across cancer lineages are PSAT1, ALOX5AP, and GPT2. Each is linked with PHGDH in more than 6 cancer types. Because this analysis shows association rather than direction, both PHGDH-to-partner and partner-to-PHGDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHGDH versus PSAT1 in BRCA, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHGDH→partner) and Y-score (partner→PHGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PSAT1 →	+1.655	+0.723	<.001	<.001	3	7
OV	ALOX5AP →	-1.164	-0.713	.001	<.001	3	6
BRCA	GPT2 →	+1.067	+0.752	<.001	<.001	3	6
HNSC	TMEM97 →	+0.900	+0.659	.001	<.001	3	5
CCRCC	NBL1 →	-1.078	-0.519	<.001	<.001	3	5
OV	ISG20 →	-0.899	-0.759	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,518 associations by consensus.

PHGDH vs PSAT1 — BRCA

Explore this scatter interactively →