PHGDH

Across TCGA patient cohorts, PHGDH mutation is significantly associated with the RNA expression of many other genes, with 943 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHGDH-associated genes across cancer lineages are TIMM9P3, RPS27P5, and RN7SKP210. Each is linked with PHGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both PHGDH-to-partner and partner-to-PHGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM9P3 grouped by PHGDH-low versus PHGDH-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHGDH→partner) and Y-score (partner→PHGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TIMM9P3 →	+0.140	+4.296	<.001	<.001	3	2
LUSC	RPS27P5 →	+0.133	+3.569	<.001	.005	3	2
LUSC	RN7SKP210 →	+0.263	+3.333	<.001	.004	3	2
LUSC	PCMTD1P2 →	+0.080	+3.324	.005	.008	3	2
LUSC	SELENOTP2 →	+0.180	+3.391	<.001	.003	3	2
LIHC	OR8B6P →	+0.039	+4.647	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 943 associations by consensus.

TIMM9P3 by PHGDH expression — LUSC

Explore this box plot interactively →