PHGDH

Across TCGA patient cohorts, PHGDH mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHGDH-associated genes across cancer lineages are Di-Ras3, A-Raf_pS299, and ACC_pS79. Each is linked with PHGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both PHGDH-to-partner and partner-to-PHGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by PHGDH-low versus PHGDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHGDH→partner) and Y-score (partner→PHGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.121	-1.807	.047	.027	3	2
UCEC	A-Raf_pS299 →	-0.111	-2.321	.024	.006	3	1
UCEC	ACC_pS79 →	+0.296	+2.179	.038	.034	3	1
UCEC	GSK-3_pS9 →	+0.354	+1.807	.034	.027	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.455	+3.169	.009	.018	3	1
UCEC	IRS1 →	-0.182	-2.459	.033	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Di-Ras3 by PHGDH expression — UCEC

Explore this box plot interactively →