PHGDH

Across TCGA cell cohorts, PHGDH RNA expression is significantly associated with the go_rna of many other GO terms, with 2,754 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHGDH-associated GO terms across cancer lineages are Serine family amino acid biosynthetic process, L-serine metabolic process, and L-serine biosynthetic process. Each is linked with PHGDH in more than 17 cancer types. Because this analysis shows association rather than direction, both PHGDH-to-partner and partner-to-PHGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serine family amino acid biosynthetic process grouped by PHGDH-low versus PHGDH-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHGDH→partner) and Y-score (partner→PHGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Serine family amino acid biosynthetic process →	+0.284	+2.515	<.001	<.001	3	18
LUNG_SCLC	L-serine metabolic process →	+0.227	+1.981	<.001	.002	3	17
BREAST	L-serine biosynthetic process →	+0.315	+1.924	.003	<.001	3	17
PANCREAS	Amino acid biosynthetic process →	+0.166	+2.616	<.001	<.001	3	17
PANCREAS	Alpha-amino acid biosynthetic process →	+0.171	+2.626	<.001	<.001	3	16
LUNG_NSCLC_LUAD	Proteinogenic amino acid biosynthetic process →	+0.130	+1.701	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,754 associations by consensus.

Serine family amino acid biosynthetic process by PHGDH expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →