PHGDH

Across TCGA cell cohorts, PHGDH mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHGDH-associated genes across cancer lineages are KRTAP17-1, KRT33A, and OR10G7. Each is linked with PHGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both PHGDH-to-partner and partner-to-PHGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP17-1 grouped by PHGDH-low versus PHGDH-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHGDH→partner) and Y-score (partner→PHGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP17-1 →	+0.016	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRT33A →	+0.058	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE1F →	+0.113	+4.662	<.001	.005	3	1
LARGE_INTESTINE	FAM153B →	+0.440	+3.841	.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.201	+2.688	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

KRTAP17-1 by PHGDH expression — SOFT_TISSUE

Explore this box plot interactively →