PHF6

Across TCGA patient cohorts, PHF6 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF6-associated genes across cancer lineages are FoxM1, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with PHF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF6-to-partner and partner-to-PHF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PHF6-low versus PHF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF6→partner) and Y-score (partner→PHF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.188	+1.321	.016	.012	3	2
UCEC	Caspase-7-cleavedD198 →	+0.635	+1.756	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.103	-2.558	<.001	<.001	3	1
UCEC	eEF2 →	+0.305	+1.807	.004	.024	3	1
UCEC	EGFR_pY1068 →	-0.284	-3.087	<.001	<.001	3	1
UCEC	eIF4E →	+0.154	+2.128	.015	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

FoxM1 by PHF6 expression — UCEC

Explore this box plot interactively →