PHF6

Across TCGA cell cohorts, PHF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,063 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHF6-associated GO terms across cancer lineages are Mitotic spindle assembly, Sister chromatid segregation, and Nuclear chromosome segregation. Each is linked with PHF6 in more than 16 cancer types. Because this analysis shows association rather than direction, both PHF6-to-partner and partner-to-PHF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle assembly grouped by PHF6-low versus PHF6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF6→partner) and Y-score (partner→PHF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Mitotic spindle assembly →	+0.100	+0.779	<.001	<.001	3	17
BREAST	Sister chromatid segregation →	+0.094	+0.688	<.001	<.001	3	16
KIDNEY	Nuclear chromosome segregation →	+0.105	+1.063	<.001	<.001	3	15
LUNG_SCLC	Regulation of mitotic cytokinesis →	+0.146	+0.979	<.001	<.001	3	15
BONE	Negative regulation of G2/M transition of mitotic cell cycle →	+0.087	+1.030	.009	.001	2	16
LUNG_SCLC	Mitotic nuclear division →	+0.081	+0.583	<.001	.008	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,063 associations by consensus.

Mitotic spindle assembly by PHF6 expression — LUNG_SCLC

Explore this box plot interactively →