PHF3

Across TCGA pan-cancer cohorts, PHF3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PHF3 data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PHF3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PHF3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where PHF3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.226	1.000	<.001	84	view →
PDAC	OS	Quartile	II,III,IV	0.304	0.687	.001	31	view →
LSCC	OS	Quartile	All	0.927	0.690	.010	20	view →
UCEC	DFS	Quartile	II,III,IV	0.431	0.873	.044	4	view →
LUAD	OS	Median	III,IV	0.911	0.325	.013	4	view →
GBM	DFS	Median	All	0.452	0.302	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PHF3–HNSC (OS)

Open the HNSC breakdown →