PHF3

Across TCGA patient cohorts, PHF3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF3-associated genes across cancer lineages are eEF2, ASNS, and VEGFR2. Each is linked with PHF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF3-to-partner and partner-to-PHF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PHF3-low versus PHF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF3→partner) and Y-score (partner→PHF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.233	+1.584	.019	.032	3	3
UCEC	ASNS →	+0.393	+1.514	<.001	.012	3	3
BLCA	VEGFR2 →	+0.289	+1.874	.016	.049	3	2
UCEC	eIF4E →	+0.151	+1.678	.009	<.001	3	2
UCEC	GAPDH →	+0.402	+1.847	.007	.007	3	2
UCEC	mTOR_pS2448 →	-0.118	-1.696	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eEF2 by PHF3 expression — UCEC

Explore this box plot interactively →