PHF3

Across TCGA cell cohorts, PHF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,850 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHF3-associated GO terms across cancer lineages are Protein modification by small protein removal, Positive regulation of organelle assembly, and Positive regulation of double-strand break repair. Each is linked with PHF3 in more than 16 cancer types. Because this analysis shows association rather than direction, both PHF3-to-partner and partner-to-PHF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein modification by small protein removal grouped by PHF3-low versus PHF3-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF3→partner) and Y-score (partner→PHF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Protein modification by small protein removal →	+0.060	+0.873	<.001	<.001	3	17
BONE	Positive regulation of organelle assembly →	+0.058	+0.778	.001	.001	3	16
OVARY	Positive regulation of double-strand break repair →	+0.079	+0.849	<.001	<.001	3	16
BONE	Regulation of nucleotide-excision repair →	+0.102	+0.622	.005	.002	3	16
BONE	Epigenetic regulation of gene expression →	+0.097	+0.711	<.001	<.001	3	16
LUNG_SCLC	Negative regulation of binding →	+0.108	+0.514	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

Protein modification by small protein removal by PHF3 expression — BLOOD_Leukemia

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