PHF3

Across TCGA cell cohorts, PHF3 mutation is significantly associated with the RNA expression of many other genes, with 1,170 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF3-associated genes across cancer lineages are PDK1, FAF1, and TEX48. Each is linked with PHF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF3-to-partner and partner-to-PHF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1 grouped by PHF3-low versus PHF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF3→partner) and Y-score (partner→PHF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDK1 →	+0.603	+2.351	.005	.001	3	3
LARGE_INTESTINE	FAF1 →	+0.406	+2.459	.002	.006	3	3
KIDNEY	TEX48 →	+0.133	+5.000	<.001	.005	3	2
LARGE_INTESTINE	EIF3L →	+0.453	+3.257	.003	.002	3	2
LARGE_INTESTINE	TMEM33 →	+0.619	+3.321	<.001	.002	3	2
LARGE_INTESTINE	COMMD2 →	+0.475	+2.265	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,170 associations by consensus.

PDK1 by PHF3 expression — LARGE_INTESTINE

Explore this box plot interactively →