PHF24

Across TCGA pan-cancer cohorts, PHF24 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PHF24 data layer compared with 20 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PHF24 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHF24 expression acts as an unfavorable survival marker.

CESC, READ, and COAD are the cancer types where PHF24 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	30	view →
READ	OS	Median	III,IV	0.289	0.932	<.001	21	view →
COAD	OS	Median	All	0.471	0.873	.001	10	view →
LUSC	OS	Median	All	0.003	0.819	<.001	8	view →
SKCM	DFS	Median	III,IV	0.063	0.648	.003	7	view →
SARC	OS	Median	All	0.029	0.828	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PHF24–CESC (DFS)

Open the CESC breakdown →