PHF24

Across TCGA patient cohorts, PHF24 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF24-associated genes across cancer lineages are Rab25, ASNS, and ATM. Each is linked with PHF24 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF24-to-partner and partner-to-PHF24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by PHF24-low versus PHF24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF24→partner) and Y-score (partner→PHF24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.398	-2.321	.002	.034	3	2
UCEC	ASNS →	+0.389	+1.906	.007	.016	3	2
UCEC	ATM →	-0.553	-1.906	.002	.016	3	2
UCEC	Caspase-8 →	-0.298	-3.880	.003	<.001	3	2
UCEC	4E-BP1 →	+0.338	+3.169	.001	.018	3	2
UCEC	C-Raf →	+0.176	+2.415	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Rab25 by PHF24 expression — UCEC

Explore this box plot interactively →