PHF24

Across TCGA cell cohorts, PHF24 protein abundance is significantly associated with the go_rna of many other GO terms, with 792 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PHF24-associated GO terms across cancer lineages are Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway, Negative regulation of cell proliferation involved in kidney development, and Extracellular matrix disassembly. Each is linked with PHF24 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF24-to-partner and partner-to-PHF24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway grouped by PHF24-low versus PHF24-high in BLOOD_Lymphoma.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF24→partner) and Y-score (partner→PHF24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway →	+0.110	+1.642	.009	<.001	3	3
LUNG_SCLC	Negative regulation of cell proliferation involved in kidney development →	+0.357	+1.179	<.001	.001	3	3
BLOOD_Leukemia	Extracellular matrix disassembly →	+0.184	+1.591	<.001	.001	3	3
BREAST	Translational termination →	-0.103	-1.125	.001	.002	3	2
BREAST	Renal water absorption →	+0.289	+1.187	.005	<.001	3	2
BREAST	Regulation of blood pressure →	+0.081	+1.332	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 792 associations by consensus.

Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway by PHF24 expression — BLOOD_Lymphoma

Explore this box plot interactively →