PHF21B

Across TCGA patient cohorts, PHF21B protein abundance is significantly associated with the RNA expression of many other genes, with 269 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PHF21B-associated genes across cancer lineages are MYRF, ZNF331, and H3-3B. Each is linked with PHF21B in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF21B-to-partner and partner-to-PHF21B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHF21B versus MYRF in BRCA, with a Pearson correlation of -0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF21B→partner) and Y-score (partner→PHF21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYRF →	-1.025	-2.100	<.001	.003	3	1
BRCA	ZNF331 →	+0.695	+2.157	.001	.009	3	1
BRCA	H3-3B →	+0.660	+2.256	.001	.005	3	1
BRCA	SPINK7 →	+0.255	+2.324	.004	.007	3	1
BRCA	ACOX1 →	+0.867	+2.157	.003	.009	3	1
BRCA	PPIP5K1 →	+1.127	+1.547	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 269 associations by consensus.

PHF21B vs MYRF — BRCA

Explore this scatter interactively →