PHF21B

Across TCGA patient cohorts, PHF21B mutation is significantly associated with the RNA expression of many other genes, with 3,368 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF21B-associated genes across cancer lineages are RNA5SP408, YARS1, and RNA5SP419. Each is linked with PHF21B in more than 3 cancer types. Because this analysis shows association rather than direction, both PHF21B-to-partner and partner-to-PHF21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP408 grouped by PHF21B-low versus PHF21B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF21B→partner) and Y-score (partner→PHF21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP408 →	+0.577	+5.596	<.001	.001	3	4
UCEC	YARS1 →	+0.450	+2.053	<.001	<.001	3	3
LUSC	RNA5SP419 →	+0.579	+4.780	<.001	.003	3	3
LUSC	RNA5SP413 →	+1.080	+4.666	<.001	<.001	3	3
LUSC	RNA5SP422 →	+0.629	+4.412	<.001	.006	3	3
LUSC	RNA5SP416 →	+0.525	+4.412	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,368 associations by consensus.

RNA5SP408 by PHF21B expression — LUSC

Explore this box plot interactively →