PHF21B

Across TCGA patient cohorts, PHF21B mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF21B-associated genes across cancer lineages are EGFR_pY1068, JNK2, and MEK1. Each is linked with PHF21B in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF21B-to-partner and partner-to-PHF21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PHF21B-low versus PHF21B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF21B→partner) and Y-score (partner→PHF21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR_pY1068 →	+0.136	+2.186	.028	.032	3	3
UCEC	JNK2 →	+0.224	+1.901	<.001	.028	3	2
UCEC	MEK1 →	+0.398	+2.502	.001	.001	3	2
UCEC	PCNA →	+0.239	+2.584	<.001	.001	3	2
UCEC	Annexin-1 →	+0.544	+2.321	.002	.005	3	2
UCEC	ATM →	-0.417	-1.794	.006	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

EGFR_pY1068 by PHF21B expression — SKCM

Explore this box plot interactively →