PHF21B

Across TCGA cell cohorts, PHF21B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,065 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHF21B-associated GO terms across cancer lineages are Positive regulation of transmembrane transport, Positive regulation of monoatomic ion transport, and Regulation of DNA repair. Each is linked with PHF21B in more than 10 cancer types. Because this analysis shows association rather than direction, both PHF21B-to-partner and partner-to-PHF21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transmembrane transport grouped by PHF21B-low versus PHF21B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF21B→partner) and Y-score (partner→PHF21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of transmembrane transport →	-0.062	-1.332	.008	<.001	2	11
BONE	Positive regulation of monoatomic ion transport →	-0.106	-1.393	<.001	<.001	3	10
LUNG_SCLC	Regulation of DNA repair →	+0.061	+2.298	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of monoatomic cation transmembrane transport →	-0.061	-0.758	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of monoatomic ion transmembrane transport →	-0.077	-0.888	<.001	<.001	3	9
OESOPHAGUS	Positive regulation of potassium ion transmembrane transport →	-0.260	-1.286	.001	.005	1	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,065 associations by consensus.

Positive regulation of transmembrane transport by PHF21B expression — BONE

Explore this box plot interactively →