PHF21B

Across TCGA cell cohorts, PHF21B mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PHF21B-associated genes across cancer lineages are DUSP29, TEX49, and FABP12. Each is linked with PHF21B in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF21B-to-partner and partner-to-PHF21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUSP29 grouped by PHF21B-low versus PHF21B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF21B→partner) and Y-score (partner→PHF21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DUSP29 →	+0.021	+4.169	<.001	.008	3	2
CNS	TEX49 →	+0.027	+4.169	<.001	.008	3	2
BLOOD_Leukemia	FABP12 →	+0.058	+4.201	<.001	.001	3	2
SKIN	PPEF2 →	+0.023	+3.877	<.001	.003	3	2
SOFT_TISSUE	PNPLA5 →	+0.397	+4.058	<.001	.001	3	1
SOFT_TISSUE	HBM →	+0.065	+3.584	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

DUSP29 by PHF21B expression — CNS

Explore this box plot interactively →