PHF20L1

Across TCGA pan-cancer cohorts, PHF20L1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PHF20L1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PHF20L1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PHF20L1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where PHF20L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.971	0.887	.014	11	view →
PDAC	DFS	Tertile	IV	0.752	0.199	.024	9	view →
UCEC	DFS	Tertile	III,IV	0.518	1.000	.049	4	view →
LUAD	DFS	Median	All	0.877	0.951	.009	3	view →
GBM	OS	Median	All	0.644	0.439	.009	2	view →
CCRCC	OS	Median	All	0.741	1.000	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PHF20L1–LSCC (DFS)

Open the LSCC breakdown →