PHF20L1

Across TCGA pan-cancer cohorts, PHF20L1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PHF20L1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PHF20L1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PHF20L1 is over-expressed in tumor.

LSCC, HNSC, and LUAD are the cancer types where PHF20L1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHF20L1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.396	<.001	9	view →
HNSC	All	III,IV	+0.283	<.001	8	view →
LUAD	Male	All	+0.232	<.001	7	view →
CCRCC	Male	All	+0.097	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PHF20L1–LSCC

Open the LSCC breakdown →