PHF20L1

Across TCGA patient cohorts, PHF20L1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF20L1-associated genes across cancer lineages are Caspase-7-cleavedD198, Di-Ras3, and 4E-BP1. Each is linked with PHF20L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF20L1-to-partner and partner-to-PHF20L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PHF20L1-low versus PHF20L1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF20L1→partner) and Y-score (partner→PHF20L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.164	+3.008	.004	.019	3	3
COAD	Di-Ras3 →	-0.220	-2.991	.030	.036	3	3
UCEC	4E-BP1 →	+0.309	+1.540	<.001	.001	3	3
COAD	ACC1 →	+0.569	+3.008	.005	.019	3	2
UCEC	eIF4E →	+0.141	+1.206	.015	.009	3	2
UCEC	MEK1 →	+0.326	+1.540	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by PHF20L1 expression — COAD

Explore this box plot interactively →