PHF20

Across TCGA patient cohorts, PHF20 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF20-associated genes across cancer lineages are Gab2, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with PHF20 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF20-to-partner and partner-to-PHF20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PHF20-low versus PHF20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF20→partner) and Y-score (partner→PHF20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.266	+1.459	.021	.012	3	2
UCEC	Caspase-7-cleavedD198 →	+0.557	+1.697	.003	.012	3	2
UCEC	14-3-3_beta →	-0.095	-2.388	.003	.002	3	1
UCEC	eEF2 →	+0.280	+1.222	.015	.035	3	1
UCEC	EGFR_pY1068 →	-0.254	-1.716	.001	.003	3	1
UCEC	eIF4E →	+0.139	+2.598	.042	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Gab2 by PHF20 expression — UCEC

Explore this box plot interactively →