PHF20

Across TCGA cell cohorts, PHF20 mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF20-associated genes across cancer lineages are PIM3, OR56A5, and OR10G2. Each is linked with PHF20 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF20-to-partner and partner-to-PHF20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIM3 grouped by PHF20-low versus PHF20-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF20→partner) and Y-score (partner→PHF20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PIM3 →	+0.712	+3.364	<.001	.002	3	2
LUNG_NSCLC_LUAD	OR56A5 →	+0.087	+4.887	<.001	.009	3	2
STOMACH	OR10G2 →	+0.027	+4.285	<.001	.007	3	2
BREAST	TGM6 →	+0.012	+2.990	.001	.007	3	1
BREAST	ZNF80 →	+0.059	+3.361	<.001	.001	3	1
BREAST	TMEM207 →	+0.086	+3.087	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

PIM3 by PHF20 expression — LARGE_INTESTINE

Explore this box plot interactively →