PHF19

Across TCGA patient cohorts, PHF19 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF19-associated genes across cancer lineages are Notch1, C-Raf, and eEF2. Each is linked with PHF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF19-to-partner and partner-to-PHF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PHF19-low versus PHF19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF19→partner) and Y-score (partner→PHF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.119	+1.415	.024	.046	3	2
UCEC	C-Raf →	+0.236	+3.321	<.001	<.001	3	2
UCEC	eEF2 →	+0.309	+2.115	.021	.017	3	1
UCEC	EGFR_pY1068 →	-0.270	-3.321	.004	<.001	3	1
UCEC	eIF4E →	+0.207	+2.662	.008	<.001	3	1
UCEC	A-Raf_pS299 →	-0.185	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Notch1 by PHF19 expression — UCEC

Explore this box plot interactively →