PHF19

Across TCGA cell cohorts, PHF19 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,407 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PHF19-associated GO terms across cancer lineages are Mitotic spindle assembly checkpoint signaling, Spindle assembly checkpoint signaling, and Mitotic spindle checkpoint signaling. Each is linked with PHF19 in more than 16 cancer types. Because this analysis shows association rather than direction, both PHF19-to-partner and partner-to-PHF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle assembly checkpoint signaling grouped by PHF19-low versus PHF19-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF19→partner) and Y-score (partner→PHF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mitotic spindle assembly checkpoint signaling →	+0.142	+1.082	.002	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Spindle assembly checkpoint signaling →	+0.142	+1.082	.002	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Mitotic spindle checkpoint signaling →	+0.142	+1.082	.002	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.158	+1.095	.002	.003	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome separation →	+0.158	+1.095	.002	.003	3	16
BREAST	Positive regulation of chromosome condensation →	+0.175	+1.214	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,407 associations by consensus.

Mitotic spindle assembly checkpoint signaling by PHF19 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →