PHF19

Across TCGA cell cohorts, PHF19 mutation is significantly associated with the mutation status of many other genes, with 3,584 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF19-associated genes across cancer lineages are YEATS2, ABCA2, and PPP1R13B. Each is linked with PHF19 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF19-to-partner and partner-to-PHF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YEATS2 grouped by PHF19-low versus PHF19-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF19→partner) and Y-score (partner→PHF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	YEATS2 →	+4.415	+4.977	.007	.007	1	3
BLOOD_Leukemia	ABCA2 →	+2.079	+2.935	.004	.004	1	3
OVARY	PPP1R13B →	+4.415	+4.977	.007	.007	1	3
BLOOD_Leukemia	SETD1A →	+2.260	+3.101	.002	.002	1	3
LARGE_INTESTINE	MYO18B →	+1.691	+2.479	.008	.008	1	3
BLOOD_Leukemia	SCAF4 →	+2.845	+3.584	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,584 associations by consensus.

YEATS2 by PHF19 expression — OVARY

Explore this box plot interactively →