PHF19

Across TCGA cell cohorts, PHF19 mutation is significantly associated with the drug of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF19-associated genes across cancer lineages are KRAS (G12C) Inhibitor-12, Niraparib, and AZD5153. Each is linked with PHF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF19-to-partner and partner-to-PHF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRAS (G12C) Inhibitor-12 grouped by PHF19-low versus PHF19-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF19→partner) and Y-score (partner→PHF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.495	+2.646	.048	.047	3	2
LARGE_INTESTINE	Niraparib →	+0.403	+2.646	.023	.047	3	1
LARGE_INTESTINE	AZD5153 →	+0.586	+2.649	.019	.046	3	1
BLOOD_Leukemia	TWS119 →	+0.545	+2.641	.047	.049	3	1
LARGE_INTESTINE	AZD2014 →	+0.571	+2.649	.029	.046	1	1
LARGE_INTESTINE	AZD1208 →	+0.367	+2.649	.034	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KRAS (G12C) Inhibitor-12 by PHF19 expression — LARGE_INTESTINE

Explore this box plot interactively →