PHF14

Across TCGA pan-cancer cohorts, PHF14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PHF14 data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PHF14 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PHF14 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where PHF14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.729	1.000	.018	8	view →
HNSC	DFS	Quartile	IV	0.482	0.896	.005	7	view →
GBM	OS	Quartile	All	0.629	0.379	.042	2	view →
PDAC	OS	Tertile	All	0.428	0.654	.036	2	view →
LSCC	OS	Quartile	All	0.892	0.677	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PHF14–CCRCC (OS)

Open the CCRCC breakdown →