PHF14

Across TCGA patient cohorts, PHF14 mutation is significantly associated with the RNA expression of many other genes, with 2,383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF14-associated genes across cancer lineages are YWHAZP1, GOT1, and OR10A7. Each is linked with PHF14 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF14-to-partner and partner-to-PHF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YWHAZP1 grouped by PHF14-low versus PHF14-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF14→partner) and Y-score (partner→PHF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	YWHAZP1 →	+0.078	+5.063	<.001	.001	3	3
UCEC	GOT1 →	+0.321	+1.922	.003	<.001	3	3
SCLC	OR10A7 →	+0.085	+5.624	<.001	.003	3	2
CESC	LINC00320 →	+0.031	+3.934	<.001	.005	3	2
HNSC	RNU6-1093P →	+0.390	+5.025	.001	.002	3	2
LIHC	RNU6ATAC29P →	+0.363	+6.479	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,383 associations by consensus.

YWHAZP1 by PHF14 expression — HNSC

Explore this box plot interactively →