PHF14

Across TCGA patient cohorts, PHF14 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF14-associated genes across cancer lineages are FoxM1, EGFR_pY1068, and Annexin-1. Each is linked with PHF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF14-to-partner and partner-to-PHF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PHF14-low versus PHF14-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF14→partner) and Y-score (partner→PHF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.363	+3.179	.009	.010	3	2
UCEC	EGFR_pY1068 →	-0.263	-1.999	.001	.002	3	2
UCEC	Annexin-1 →	+0.493	+2.019	.003	.005	3	2
UCEC	ATM →	-0.473	-1.765	.001	.013	3	2
UCEC	Chk2_pT68 →	-0.131	-1.848	.029	.049	3	2
LUSC	ACC_pS79 →	+0.348	+2.821	.043	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

FoxM1 by PHF14 expression — LUSC

Explore this box plot interactively →