PHF14

Across TCGA cell cohorts, PHF14 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,694 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PHF14-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Regulation of isotype switching to IgG isotypes, and Regulation of nucleotide-excision repair. Each is linked with PHF14 in more than 17 cancer types. Because this analysis shows association rather than direction, both PHF14-to-partner and partner-to-PHF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by PHF14-low versus PHF14-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF14→partner) and Y-score (partner→PHF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of isotype switching to IgG isotypes →	+0.160	+1.014	.001	.001	2	18
OVARY	Regulation of isotype switching to IgG isotypes →	+0.142	+0.901	<.001	<.001	3	15
BLOOD_Lymphoma	Regulation of nucleotide-excision repair →	+0.073	+0.909	<.001	<.001	3	13
BONE	Germinal center B cell differentiation →	+0.471	+1.261	<.001	<.001	3	13
OVARY	Meiotic mismatch repair →	+0.128	+1.003	<.001	<.001	3	13
BONE	Mismatch repair →	+0.133	+1.525	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,694 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by PHF14 expression — STOMACH

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