PHF14

Across TCGA cell cohorts, PHF14 mutation is significantly associated with the RNA expression of many other genes, with 808 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF14-associated genes across cancer lineages are PFN3, KLF1, and PSPC1. Each is linked with PHF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF14-to-partner and partner-to-PHF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by PHF14-low versus PHF14-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF14→partner) and Y-score (partner→PHF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PFN3 →	+0.098	+4.228	<.001	.001	3	2
SKIN	KLF1 →	+0.079	+3.295	.009	.006	3	2
SKIN	PSPC1 →	+0.530	+3.301	.003	.003	3	2
SKIN	EP400 →	+0.483	+3.212	.005	.006	3	2
LARGE_INTESTINE	OAS2 →	-1.313	-2.459	.005	.003	3	2
LARGE_INTESTINE	MRPL37 →	+0.385	+2.404	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 808 associations by consensus.

PFN3 by PHF14 expression — BREAST

Explore this box plot interactively →