PHF13

Across TCGA patient cohorts, PHF13 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF13-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with PHF13 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF13-to-partner and partner-to-PHF13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PHF13-low versus PHF13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF13→partner) and Y-score (partner→PHF13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.252	+2.906	.004	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.133	-2.449	.011	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-2.209	.014	.011	3	1
UCEC	MEK1 →	+0.354	+2.222	.022	.011	3	1
UCEC	mTOR_pS2448 →	-0.167	-3.156	.008	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.433	-2.321	.023	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by PHF13 expression — UCEC

Explore this box plot interactively →