PHF12

Across TCGA patient cohorts, PHF12 protein abundance is significantly associated with the RNA expression of many other genes, with 8,325 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PHF12-associated genes across cancer lineages are ZNF397, ZSCAN16, and SPAG5. Each is linked with PHF12 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHF12-to-partner and partner-to-PHF12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHF12 versus ZNF397 in LSCC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF12→partner) and Y-score (partner→PHF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF397 →	+0.460	+0.202	.008	.003	3	4
UCEC	ZSCAN16 →	+0.685	+0.238	.002	<.001	3	4
LSCC	SPAG5 →	+0.875	+0.268	<.001	<.001	3	4
HNSC	PHOSPHO2 →	+0.856	+0.468	.003	.001	3	4
HNSC	RSKR →	+0.808	+0.436	<.001	.001	3	4
HNSC	PROCA1 →	+0.663	+0.397	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,325 associations by consensus.

PHF12 vs ZNF397 — LSCC

Explore this scatter interactively →