PHF12

Across TCGA patient cohorts, PHF12 mutation is significantly associated with the RNA expression of many other genes, with 4,573 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF12-associated genes across cancer lineages are RNA5SP411, RNA5SP412, and RNU6-960P. Each is linked with PHF12 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF12-to-partner and partner-to-PHF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by PHF12-low versus PHF12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF12→partner) and Y-score (partner→PHF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+0.705	+1.586	.001	.002	3	3
UCEC	RNA5SP412 →	+0.320	+1.765	.007	.001	3	3
CESC	RNU6-960P →	+0.109	+4.247	<.001	.007	3	3
BRCA	RNA5SP147 →	+0.190	+4.739	.001	.005	3	3
UCEC	TNFSF9 →	+1.194	+4.000	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.710	+2.890	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,573 associations by consensus.

RNA5SP411 by PHF12 expression — UCEC

Explore this box plot interactively →