PHF12

Across TCGA patient cohorts, PHF12 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF12-associated genes across cancer lineages are 4E-BP1, STAT3_pY705, and YAP_pS127. Each is linked with PHF12 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF12-to-partner and partner-to-PHF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PHF12-low versus PHF12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF12→partner) and Y-score (partner→PHF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.352	+3.807	<.001	<.001	3	3
UCEC	STAT3_pY705 →	-0.421	-2.127	<.001	<.001	3	2
SKCM	YAP_pS127 →	-0.505	-3.000	.013	.036	2	3
STAD	Claudin-7 →	+0.892	+3.000	.008	.036	3	2
SKCM	Heregulin →	+0.227	+3.000	.021	.036	3	2
UCEC	eIF4E →	+0.185	+3.472	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1 by PHF12 expression — UCEC

Explore this box plot interactively →