PHF12

Across TCGA cell cohorts, PHF12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,769 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHF12-associated GO terms across cancer lineages are Regulation of DNA repair, Positive regulation of T-helper 17 cell lineage commitment, and Epigenetic regulation of gene expression. Each is linked with PHF12 in more than 16 cancer types. Because this analysis shows association rather than direction, both PHF12-to-partner and partner-to-PHF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by PHF12-low versus PHF12-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF12→partner) and Y-score (partner→PHF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of DNA repair →	+0.089	+0.894	.001	.006	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of T-helper 17 cell lineage commitment →	+0.195	+0.839	.001	.004	3	17
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.084	+0.689	<.001	<.001	3	17
BONE	Protein-DNA complex organization →	+0.093	+1.044	.001	<.001	3	17
STOMACH	Negative regulation of transcription initiation by RNA polymerase II →	+0.140	+0.680	<.001	.003	3	16
KIDNEY	mRNA alternative polyadenylation →	+0.089	+0.718	.002	.005	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,769 associations by consensus.

Regulation of DNA repair by PHF12 expression — BONE

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