PHF12

Across TCGA cell cohorts, PHF12 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHF12-associated genes across cancer lineages are OR10K1, ZNF831, and GSC2. Each is linked with PHF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF12-to-partner and partner-to-PHF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K1 grouped by PHF12-low versus PHF12-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF12→partner) and Y-score (partner→PHF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR10K1 →	+0.006	+5.285	<.001	.003	3	2
LARGE_INTESTINE	ZNF831 →	+0.010	+2.688	<.001	.008	3	2
LARGE_INTESTINE	GSC2 →	+0.086	+2.688	<.001	.008	3	2
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
CNS	UGT2B10 →	+0.039	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

OR10K1 by PHF12 expression — STOMACH

Explore this box plot interactively →